abstract：BACKGROUND:Lung contusion (LC) is a unique direct and focal insult that is considered a major risk factor for the initiation of acute lung injury and acute respiratory distress syndrome. We have shown recently that consumption of nitric oxide (due to excess superoxide) resulting in peroxynitrite formation leads to decr...

journal_title：Surgery

authors： Suresh MV,Yu B,Lakshminrusimha S,Machado-Aranda D,Talarico N,Zeng L,Davidson BA,Pennathur S,Raghavendran K

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Many postoperative concerns after common general operative procedures may be addressed over the phone, thereby saving time and resources for both the patient and surgeon. METHODS:Over a 6-month time period, patients who underwent laparoscopic cholecystectomy, appendectomy for uncomplicated appendicitis, and...

journal_title：Surgery

authors： Wright GP,Wolf AM,Ambrosi G,Dull MB,Chung MH

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Laparoscopic ultrasound (LUS) is a method of intraoperative bile duct imaging that can be used prior to any potentially hazardous dissection. The purpose of this study was to determine whether LUS could permit safe laparoscopic completion of difficult cholecystectomy (LC) cases and to assess whether its use ...

journal_title：Surgery

authors： Gwinn EC,Daly S,Deziel DJ

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Routine, whole-body computed tomography imaging (PAN-SCAN) has been shown to identify unexpected injuries and alter the management of patients presenting with blunt trauma. We sought to characterize the changes in practice over time and the utility of PAN-SCAN imaging in elderly patients who fall and requi...

journal_title：Surgery

authors： Dwyer CR,Scifres AM,Stahlfeld KR,Corcos AC,Ziembicki JA,Summers JI,Peitzman AB,Billiar TR,Sperry JL

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:Enhancer of zeste homologue 2 (EZH2), a component of the chromatin modification protein complex, is upregulated in pancreatic ductal adenocarcinoma (PDAC), whereas loss of p53 and its downstream target, p21(waf1/cip1), is also observed frequently. We sought to investigate the role of the p53-p21(waf1/cip1) path...

journal_title：Surgery

authors： Batchu RB,Qazi AM,Gruzdyn OV,Semaan A,Seward SM,Chamala S,Dhulipala VB,Bouwman DL,Weaver DW,Gruber SA

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Gastric cancer is an aggressive disease, and overall changes in incidence rates have been noted. There are conflicting data on whether young patients have worse outcomes than older patients; the roles of tumor biology and access to care are critical to answering this question. Our objectives were to explore ...

journal_title：Surgery

authors： Nguyen DK,Maggard-Gibbons M

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:We sought to determine the long-term effects of ABO-compatible donors (ACD) in adult cardiac transplantation (OHT). METHODS:The United Network for Organ Sharing database was examined for adult OHT from 2000 to 2010. RESULTS:Of 20,353 patients undergoing OHT, 3,046 (15%) were with ACD. Recipients of ACD wer...

journal_title：Surgery

authors： Taghavi S,Jayarajan SN,Wilson LM,Komaroff E,Mangi AA

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Policies that mandate colorectal screening coverage by private insurers are associated with increased use of screening procedures. We seek to understand whether such mandates have improved access to care and short-term operative outcomes for patients undergoing operations of the colon and rectum (OCR). ME...

journal_title：Surgery

authors： Bansal N,Sonnenberg EM,Meise CK,Reinke CE,Karakousis GC,Bartlett EK,Mahmoud NN,Roses RE,Kelz RR

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Only annual mammography and physical examination are recommended for the post-treatment surveillance of early stage breast cancer. METHODS:We used Texas Cancer Registry-Medicare linked data (2001-2007) to identify physician visits and use of mammography, magnetic resonance imaging (MRI), computed tomography...

journal_title：Surgery

authors： Parmar AD,Sheffield KM,Vargas GM,Han Y,Chao C,Riall TS

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:This study was conducted to identify the relevant cutoff value and to evaluate the usefulness of postoperative-stimulated serum thyroglobulin (Tg) at the time of (131)I ablation for the prediction of disease status in patients with differentiated thyroid carcinoma (DTC) who received high-dose (131)I ablation...

journal_title：Surgery

authors： Lee JI,Chung YJ,Cho BY,Chong S,Seok JW,Park SJ

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Meckel's diverticulum (MD) is one of the most common congenital gastrointestinal malformations. It is difficult to make a preoperative diagnosis of MD. To date, few data are available describing the diagnosis of MD by double-balloon enteroscopy (DBE) and capsule endoscopy (CE). METHODS:To assess the value o...

journal_title：Surgery

authors： He Q,Zhang YL,Xiao B,Jiang B,Bai Y,Zhi FC

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is among the most common malignant neoplasms worldwide. Only few data on HCC in noncirrhotic livers without viral hepatitis in Western countries are available. The purpose of this study was to define the outcomes and potential prognostic factors associated with survival after h...

journal_title：Surgery

authors： Faber W,Sharafi S,Stockmann M,Denecke T,Sinn B,Puhl G,Bahra M,Malinowski MB,Neuhaus P,Seehofer D

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Tumor-associated lymphatic networks are the primary routes for tumor cell dissemination and metastasis. Behind the background of possible lymphangiogenesis-associated therapies, the clinical impact of lymphangiogenesis (measured by lymphatic microvessel density [LMVD]) and specific lymphovascular invasion (L...

journal_title：Surgery

authors： Schoppmann SF,Jesch B,Zacherl J,Riegler MF,Friedrich J,Birner P

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Despite the accumulation of favorable results from laparoscopic liver resection (LLR), centrally located tumors close to the hilum, major hepatic veins, or inferior vena cava (IVC) are still considered contraindications for LLR. We evaluated the feasibility and safety of LLR for centrally located tumors. ME...

journal_title：Surgery

authors： Yoon YS,Han HS,Cho JY,Kim JH,Kwon Y

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Over the years, several modifications of the Scopinaro biliopancreatic diversion (BPD) have been proposed. This retrospective study reported the results of 15 years of follow-up after open BPD coupled with a type of transient gastroplasty (TG) and duodenal switch (DS), termed BPD-TG with DS. METHODS:Data we...

journal_title：Surgery

authors： Pata G,Crea N,Di Betta E,Bruni O,Vassallo C,Mittempergher F

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Secondary peritonitis continues to carry a high mortality rate despite the aggressive use of imaging, drainage, and antibiotics. Although host factors and microbial burden contribute to the outcome of peritonitis, we propose a role for bacterial virulence as a determinant of outcome from peritonitis. Bacteri...

journal_title：Surgery

authors： Babrowski T,Romanowski K,Fink D,Kim M,Gopalakrishnan V,Zaborina O,Alverdy JC

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:We aimed to assess the feasibility, safety, and efficacy of radiofrequency (RF) ablation for the treatment of large (≥5 cm in greatest diameter) hepatic hemangiomas. METHODS:Thirty-six patients (15 male, 21 female; mean age 50 years) with 41 hepatic hemangiomas ≥5 cm in diameter were enrolled and treated wit...

journal_title：Surgery

authors： Gao J,Ke S,Ding XM,Zhou YM,Qian XJ,Sun WB

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Pasireotide (SOM230), a long-acting somatostatin analogue (LAR), has improved agonist activity at somatostatin receptors. We tested the effect of SOM230 on insulin secretion, serum glucose concentrations, tumor growth, and survival using an MEN1 transgenic mouse model. METHODS:Eight 12-month-old conditional...

journal_title：Surgery

authors： Quinn TJ,Yuan Z,Adem A,Geha R,Vrikshajanani C,Koba W,Fine E,Hughes DT,Schmid HA,Libutti SK

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Despite development of current targeted therapies for medullary thyroid cancer (MTC), long-term survival remains unchanged. Recently isolated novel withanolide compounds from Solanaceae physalis are highly potent against MTCs. We hypothesize that these withanolides uniquely inhibit RET phosphorylation and th...

journal_title：Surgery

authors： Samadi AK,Bazzill J,Zhang X,Gallagher R,Zhang H,Gollapudi R,Kindscher K,Timmermann B,Cohen MS

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:A laparoscopic approach to adrenalectomy has become the procedure of choice for most adrenal resections. We hypothesized that laparoscopic adrenalectomy is less likely to result in intensive care unit (ICU) level complications or death than open adrenalectomy, despite baseline comorbidity mix. METHODS:Using...

journal_title：Surgery

authors： Eichhorn-Wharry LI,Talpos GB,Rubinfeld I

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Prophylactic central neck dissection (PCND) for papillary thyroid carcinoma (PTC) is controversial. We compared 3 different approaches to the management of central compartment nodes in patients with clinically unifocal and N0 PTC. METHODS:A total of 186 patients were prospectively assigned to one of the fol...

journal_title：Surgery

authors： Raffaelli M,De Crea C,Sessa L,Giustacchini P,Revelli L,Bellantone C,Lombardi CP

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Patients with primary hyperparathyroidism often lack classic symptoms but can have reductions in bone mineral density and increased fracture risk. We sought to determine bone mineral density improvement after successful surgery and associated factors. METHODS:A review of patients with osteopenia or osteopor...

journal_title：Surgery

authors： Dy BM,Grant CS,Wermers RA,Kearns AE,Huebner M,Harmsen WS,Thompson GB,Farley DR,Richards ML

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:There are few population-based studies addressing the survival after resection for esophageal cancer. This study represents an update of a nationwide Swedish cohort initiated in 1987. METHODS:Based on data from the Swedish Patient Register, Swedish Cancer Register, and histopathologic records, 1,008 patient...

journal_title：Surgery

authors： Rutegård M,Charonis K,Lu Y,Lagergren P,Lagergren J,Rouvelas I

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The clinical value of synbiotics in patients undergoing esophagectomy remains unclear. This study investigated the effects of synbiotics on intestinal microflora and surgical outcomes in a clinical setting. METHODS:We studied 70 patients with esophageal cancer who were scheduled to undergo esophagectomy. Th...

journal_title：Surgery

authors： Tanaka K,Yano M,Motoori M,Kishi K,Miyashiro I,Ohue M,Ohigashi H,Asahara T,Nomoto K,Ishikawa O

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Cell migration is an integral part of the development of intimal hyperplasia, and proteases are pivotal components in the process. Cell migration in response to urokinase is mediated through the aminoterminal fragment (ATF) of the protein. This study examines the role of NAD(P)H oxidase during epidermal grow...

journal_title：Surgery

authors： Duru EA,Fu Y,Davies MG

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To assess trainee satisfaction in their surgery residency with a validated instrument and identify the contributing factors. BACKGROUND:Currently, surgery is deemed unattractive by medical students and ignored by many candidates planning to enter an academic career. New insights on the rational for such lack...

journal_title：Surgery

authors： von Websky MW,Oberkofler CE,Rufibach K,Raptis DA,Lehmann K,Hahnloser D,Clavien PA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Therapeutic anticoagulation in the geriatric trauma population is increasingly common. Fresh frozen plasma, while the criterion standard for correction, has limited availability and associated transfusion risks. We examined our use of prothrombin complex concentrate for immediate reversal of therapeutically ...

journal_title：Surgery

authors： Quick JA,Bartels AN,Coughenour JP,Barnes SL

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:Computed tomography (CT) has become an essential tool in the assessment of the stable trauma patient. Intravenous (i.v.) contrast is commonly relied upon to provide superior image quality, particularly for solid-organ injury. However, a substantial proportion of injured patients have contraindications to i...

journal_title：Surgery

authors： Murken DR,Weis JJ,Hill GC,Alarcon LH,Rosengart MR,Forsythe RM,Marshall GT,Billiar TR,Peitzman AB,Sperry JL

更新日期：2012-10-01 00:00:00

abstract：:Until recently, it was unclear whether calcium is more than a bystander in the development of acute pancreatitis. Now important evidence has been accumulated supporting a pivotal role of intracellular levels of calcium in the early pathogenesis of the disease. A sustained increase of cytosolic calcium concentrations, ...

journal_title：Surgery

authors： Frick TW

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer worldwide. Greater than 90% of SCCHN of the oropharynx overexpress the epidermal growth factor receptor (EGFR or HER1). Cetuximab (Erbitux-TM) is a humanized anti-HER1 monoclonal antibody (mAb) that binds to HER1 overexpress...

journal_title：Surgery

authors： Luedke E,Jaime-Ramirez AC,Bhave N,Roda J,Choudhary MM,Kumar B,Teknos TN,Carson WE 3rd

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Depression has been associated with delayed presentation, inadequate treatment, and poor survival in patients with cancer. METHODS:Using Surveillance, Epidemiology and End Results and Medicare linked data (1992-2005), we identified patients with pancreatic adenocarcinoma (N = 23,745). International classifi...

journal_title：Surgery

authors： Boyd CA,Benarroch-Gampel J,Sheffield KM,Han Y,Kuo YF,Riall TS

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Discussion of the volume-outcome relationship in pancreatic surgery has gained increasing interest. Currently, no data describe the situation in Germany. Pursuant to a recent legislative reform, a threshold of 10 operations per year was introduced for pancreatic surgery in 2006. This study describes the situ...

journal_title：Surgery

authors： Alsfasser G,Kittner J,Eisold S,Klar E

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:p38-Alpha mitogen-activated protein kinase (p38-MAPK) is a tumor suppressor often mutated in human cancers, but its specific role in colorectal cancer is not completely understood. Previous studies have found that p38-MAPK activity inhibits epithelial proliferation and promotes apoptosis in the intestine. Th...

journal_title：Surgery

authors： Wakeman D,Schneider JE,Liu J,Wandu WS,Erwin CR,Guo J,Stappenbeck TS,Warner BW

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Outcomes after operative management of benign hepatic lesions are ill-defined. We sought to define patient-reported quality of life (QOL) postoperatively for benign hepatic tumors. METHODS:Patients who underwent surgery for benign liver lesions (n = 255) were invited to complete a QOL survey designed using ...

journal_title：Surgery

authors： Kneuertz PJ,Marsh JW,de Jong MC,Covert K,Hyder O,Hirose K,Schulick RD,Choti MA,Geller DA,Pawlik TM

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:High-dose perioperative corticosteroids are the standard of care for steroid-treated patients undergoing surgery. There is little evidence, however, to support this practice. We investigated the safety of perioperative low-dose steroids in patients with inflammatory bowel disease (IBD) undergoing major color...

journal_title：Surgery

authors： Zaghiyan K,Melmed G,Murrell Z,Fleshner P

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to compare faculty ratings between live versus video-recorded resident performances and faculty versus skills coaches' ratings of video-recorded resident performances. METHODS:PGY1 residents were observed, video-recorded, and rated during a Verification of Proficiency examina...

journal_title：Surgery

authors： Rooney DM,Hungness ES,Darosa DA,Pugh CM

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Less invasive operations such as laparoscopic surgery have been developed for treating gastrointestinal malignancies. However, the advantages of video-assisted thoracoscopic surgery for esophageal cancer (VATS-e) with regard to postoperative morbidity and mortality remains controversial. METHODS:We investig...

journal_title：Surgery

authors： Tsujimoto H,Takahata R,Nomura S,Yaguchi Y,Kumano I,Matsumoto Y,Yoshida K,Horiguchi H,Hiraki S,Ono S,Yamamoto J,Hase K

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:We compared the effectiveness of n-butyl-2-cyanoacrylate (NBCA) and traditional suture for patch fixation in Lichtenstein tension-free herniorrhaphy for inguinal hernias. METHODS:A total of 110 patients with primary unilateral inguinal hernia were assigned randomly to either experimental or control groups. ...

journal_title：Surgery

authors： Shen YM,Sun WB,Chen J,Liu SJ,Wang MG

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The contribution of gastric acid to the toxicity of alkaline duodenal refluxate on the esophageal mucosa is unclear. This study compared the effect of duodenal refluxate when acid was present, decreased by proton pump inhibitors (PPI), or absent. METHODS:We randomized 136 Sprague-Dawley rats into 4 groups: ...

journal_title：Surgery

authors： Nasr AO,Dillon MF,Conlon S,Downey P,Chen G,Ireland A,Leen E,Bouchier-Hayes D,Walsh TN

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Although task training on virtual reality (VR) simulators has been shown to transfer to the operating room, to date no VR curricula have been described for advanced laparoscopic procedures. The purpose of this study was to develop a proficiency-based VR technical skills curriculum for laparoscopic colorectal...

journal_title：Surgery

authors： Palter VN,Graafland M,Schijven MP,Grantcharov TP

更新日期：2012-03-01 00:00:00